Glycogen Storage Disease is a rare genetic defect disease, which is treated by lifestyle modification, drug treatment (for symptoms such as hypoglycemia, high uric acid, infection, etc.), enzyme substitution therapy, and surgical treatment (partial hepatectomy, hepatic adenoma resection, liver transplantation and heart transplantation and other organ transplantation) according to the different subtypes. 1. Lifestyle modification: For types III, VI and V, small and frequent meals, high protein diet, limiting fat and total calories, and moderate exercise are preferred to help control blood glucose and relieve the disease. In acute attack, intravenous glucose should be injected immediately to maintain blood glucose at 4~5mmol/L. 2. Drug treatment: For type I, it can be treated by drugs, by taking metformin and glucose injection to prevent and control hypoglycemia, by using antibiotic drugs such as cefadroxil capsules and norfloxacin hydrochloride capsules for anti-infective treatment, and by taking allopurinol delayed-release tablets and allopurinol delayed-release capsules to prevent and control hyperuricemia. 3. Enzyme Replacement Therapy: This treatment is mainly used for glycogen storage disease of type I, II and IV, and its principle is to inject enzymes into the patient’s body and implant cells with normal genes into the patient’s body through bone marrow transplantation of human body, so as to improve autosomal defects. 4. Surgical treatment: Type IV surgical treatment includes partial hepatectomy, hepatic adenoma resection, liver transplantation, heart transplantation and other organ transplantation surgeries, while Type I surgical treatment mainly involves portal-ventricular vein or intestinal-ventricular vein shunt, which can improve the situation of biochemical abnormality. It is recommended that patients with glycogen storage disease should seek timely medical treatment and follow the doctor’s instructions for scientific and effective treatment.