Ankle pain in the morning may be caused by sprain, bursitis, gout and other diseases. 1. Sprain: Sprain is an acute sprain of the joint involving the surrounding ligamentous tissues, which can occur in the ankle joint. Its etiology is mostly related to strenuous exercise, improper posture, inadvertent fall and other factors. Patients manifested as severe pain, dysfunction, etc. Patients may appear to get up in the morning ankle pain. 2. Bursitis: the cause of bursitis is related to trauma, infection, rheumatoid arthritis, osteoarthritis and other factors. Patients will have symptoms such as localized swelling and pain in the joints, and the pain symptoms worsen when moving or pressing, and the patients will have ankle pain in the morning. 3. Gout: Gout may be caused by drugs, alcohol consumption, abnormalities, uric acid excretion disorders and other factors. Patients will experience joint pain, which is aggravated in the early morning, manifesting as ankle pain in the morning. There are many reasons that cause patients to have ankle pain in the morning, and it is recommended that patients go to regular hospitals and undergo relevant examinations so as to identify the causes of the disease.