Cholangiocarcinoma puncture drainage tube is usually changed once in 3-6 months. For patients with bile duct cancer that can be surgically removed, surgical removal is preferred; if surgery is not possible for the time being or the chance of surgery is lost, jaundice symptoms can be improved and obstruction symptoms can be relieved through indwelling drains. The main function of puncture drain for cholangiocarcinoma is to drain bile, which needs to be replaced once in 3-6 months under normal condition, but it depends on the patient’s wounds and the smoothness of the drain to determine the exact situation, and it needs to be replaced in advance if there is any blockage or infection, etc. In addition, indwelling drains should be replaced in advance. In addition, patients with indwelling drains need to do a good job in skin care and wound cleaning, so as to avoid infection and inflammation, leading to aggravation of the condition. If cholangiocarcinoma is suspected or diagnosed, it is recommended to go to regular hospitals to evaluate the condition and follow the doctor’s instructions for treatment, so as to avoid delaying the condition.