Is hypertension and diabetes mellitus the main factor that damages renal function? Middle-aged and elderly people’s renal function is gradually declining, the stability of the regulatory internal environment is poor, in some pathological conditions can make renal function deteriorate, there are many factors affecting renal function, the most important is hypertension and diabetes mellitus. Accompanied by diabetes mellitus hypertension treatment and drug therapy: 1, blood pressure down to 130/80mmHg or less, the best choice of ACEI or ARB, to protect the kidneys, CCB lowering blood pressure is accurate. 2.Patients are prone to coronary artery disease and so on, so highly selective beta-blockers should also be used. 3, the patient is prone to renal function damage, so small-dose diuretics should also be used. 4, emphasize the application of statins. 5, don’t forget to add aspirin. 6, diabetes itself should be controlled, healthy lifestyle.