Pterygoid sinusitis can cause severe headache and also nasal congestion and pus, etc. Usually, sinus CT can confirm the diagnosis, and usually conservative treatment can be given first, and antibiotics can be given orally, such as Clarithromycin, Amoxicillin Clavulanate Potassium, and Nasal Spray Mometasone Furoate. If headache relief is not obvious after treatment, intravenous antibiotics, such as cefotaxime sodium, may be used instead. After the treatment of the above symptoms can not be relieved, usually need to carry out surgical treatment, at present, most of the use of nasal endoscopic pterygoid sinus open surgery, open the pterygoid sinus so that the pterygoid sinus mouth open, facilitate the outflow of purulent secretions. After the operation, antibiotics should be used for 1 week, and hormone drugs should be sprayed into the nasal cavity. After the operation, the medication should be changed regularly under the nasal endoscopy, so as to avoid the narrowing or even occlusion of the sinus opening, which may cause the attack of pterygoid sinusitis again and lead to the occurrence of headache.