Typically, glucose-lowering medications do not cause straining of the bowels. Glucose-lowering medications are commonly used in the treatment of diabetes and for blood sugar control in diabetic patients. Some hypoglycemic drugs may cause gastrointestinal reactions such as nausea, vomiting, abdominal pain, and other adverse reactions after taking them, but they rarely cause fecal effort. It should be noted that the use of acarbose may cause constipation, but this is rare. Stool straining may be caused by low water intake, lack of dietary fiber in the food intake, lack of activity, or may be caused by intestinal obstruction or other disease factors. Patients who are taking hypoglycemic drugs should go to the hospital and ask the doctor to make a judgment, rather than making a blind judgment on their own.