Some antibiotics and hypoglycemic drugs can react with alcohol in a toxic manner, and it is recommended not to drink alcohol during medication and within two weeks of stopping medication, otherwise, it may be life-threatening. 1, antibacterial drugs Cephalosporins such as cefoperazone, cephalexin, cefmetazole, cefamandole, cefmento, cefmenoxime, cefotiam and metronidazole, tinidazole, furazolidone, etc. can cause dithione-like reactions, manifested as weakness of limbs, weakness, drowsiness, dizziness, hallucinations, headache, nausea, vomiting, chest tightness, flushing, convulsions, even a drop in blood pressure, respiratory depression, shock, etc., after drinking alcohol. reactions. Therefore, patients should refrain from drinking alcohol 2 days before using the above drugs and avoid drinking alcohol and taking drinks and drugs containing ethanol for 1 week after using the drugs. In addition, toluenesulfonylurea, chlorosulfonylurea, etc. can also cause the above reaction. 2, morphine Ethanol combined with morphine will produce synergistic effects. May cause poisoning, and even death. 3, sedative-hypnotic drugs diazepam, nitrazepam, clonazepam, triazolam, barbiturates and chloral hydrate and other sedative-hypnotic drugs, combined with ethanol can cause drowsiness, trance, coma, respiratory failure, and even death. 4, antipyretic and analgesic drugs aspirin, ibuprofen, diclofenac, etc., if you drink a lot of alcohol when taking such drugs, can make the gastrointestinal mucosa by the dual stimulation of drugs and ethanol, and even cause peptic ulcers or bleeding. 5, hypoglycemic drugs gliphenylurea, metformin, insulin, etc. Drinking large amounts of alcohol during the medication can cause dizziness, panic, cold sweat, shaking hands and other hypoglycemic reactions, serious cases can occur hypoglycemic coma. 6, anti-epileptic drugs long-term alcohol consumption can reduce the concentration and efficacy of phenytoin sodium, but taking drugs while drinking large amounts of alcohol can increase the blood concentration, taking sodium valproate during drinking alcohol, can enhance the central inhibitory effect. 7, anti-angina drugs isosorbide nitrate, nitroglycerin and nifedipine and other drugs during the administration of alcohol can cause excessive vasodilation, resulting in severe headaches, sudden drop in blood pressure and even shock. 8, hypotensive drugs nifedipine, hydrazidiazide, dibazol and other drugs taken with alcohol, it is easy to appear hypotension. 9, anti-allergic drugs diphenhydramine, chlorpheniramine, sebacrine, etc. taken with wine, can cause drowsiness, mental trance, coma. 10, hemostatic and anticoagulant drugs Ethanol can inhibit coagulation factors, counteract the effect of hemostatic drugs, so that the role of hemostatic drugs is reduced. 11, diuretics Furosemide, hydrochlorothiazide, etc. can lower blood pressure through urination, ethanol also has a vasodilating effect, taking diuretics while drinking alcohol, may appear dizziness, upright deficiency and other symptoms. 12, antidepressants Drinking alcohol while taking promethazine and doxepin antidepressants can have a central sedative effect.