Lymph node swelling, pain in clinical common causes are mainly the following situations: First, the patient’s body with a large number of bacterial toxin proliferation, can make the body’s lymphocytes reactive increase, manifested as local lymph node hyperplasia, enlargement, common acute purulent tonsillitis, can cause submandibular lymph nodes enlarged, pain, acute epididymitis can be caused by inguinal lymph nodes enlarged, pain. Through active anti-infection treatment to control the inflammation in the body, the enlarged lymph nodes can gradually subside, and the prognosis is relatively good. Second, patients with malignant tumors in the body with extensive proliferation, can also cause lymph node enlargement and pain symptoms, such as gastric malignant tumors, colon malignant tumors can cause intra-abdominal or retroperitoneal lymph node enlargement. Thyroid malignant tumor can cause lymph node swelling in the patient’s neck with pain. At this time, patients need to perform primary tumor resection and lymph node dissection as soon as possible, after the operation can be combined with chemotherapy and radiotherapy to remove the tumor cells in the body, patients with early disease can achieve better results.