Chromosomes are the basic substances that make up the nucleus of a cell and are the carriers of genes. Chromosomal disorders are usually classified as: 1. Quantitative aberrations including aneuploidy and aneuploidy aberrations, chromosome number increase, decrease and appearance of triploidy etc. 2. structural aberrations chromosome deletions, translocations, inversions, insertions, duplications and ring chromosomes. They can also be divided into autosomal aberrations, such as Down (trisomy 21) syndrome, Patau (trisomy 13) syndrome and Edward (trisomy 18) syndrome, and sex chromosomal aberrations, such as Turner syndrome (XO) and congenital testicular hypoplasia. The most common chromosomal disorder, trisomy 21, is characterized by a 10% lighter than normal brain weight, simple gyrus structure, small frontal lobe, thin superior temporal gyrus cortex, late myelin formation in the white matter of the brain, and underdeveloped and poorly differentiated cortical neurons. Chromosomal dysplasia is difficult to treat and has unsatisfactory outcomes, making prevention even more important. Preventive measures include the introduction of genetic counseling, chromosome testing, prenatal diagnosis and selective abortion to prevent the birth of affected children. Treatment of chromosomal anomalies is difficult and unsatisfactory, and treatment of congenital mental retardation resulting from chromosomal anomalies is also not yet available as effective drugs; herbal treatment and rehabilitation training can be tried. In clinical manifestations, IVF embryo stop or underdevelopment, prone to spontaneous abortion of and other symptoms, so we will choose donor egg IVF in order to produce a normal baby.