Ulcerative colitis taking half a month of hormones usually does not get fat. Ulcerative colitis is a chronic non-specific intestinal inflammatory disease due to immune disorders, genetics or intestinal flora dysbiosis, etc. Patients will have obvious abdominal pain and diarrhea, accompanied by mucous pus and blood stools. Currently, it can be treated clinically by using aminosalicylic acid drugs such as salazosulfapyridine, glucocorticoid drugs such as prednisone, biologics such as infliximab, or immunosuppressants such as azathioprine. However, glucocorticosteroids long-term use of certain side effects, will affect the distribution of fat, the emergence of centripetal obesity, the patient is mainly manifested as a full-moon face, buffalo back, hanging abdomen, limbs thin, etc., and some patients taking medication for half a year may appear to become fat. In addition, long-term use of glucocorticoids may also lead to osteoporosis, osteonecrosis of the femoral head, elevated blood glucose, decreased immunity, water and sodium retention and other adverse reactions. Patients with ulcerative colitis are advised to seek timely medical attention and actively undergo treatment, and medications need to be taken in strict accordance with the doctor’s instructions, not self-medication, so as not to delay or even aggravate the condition.