Diclofenac sodium enteric-coated tablets and Celecoxib which is good can not be generalized, both belong to the non-steroidal anti-inflammatory drugs, the therapeutic effect of the patient’s condition as well as the sensitivity of the drug is related to, can not be directly compared. Diclofenac sodium enteric-coated tablets and celecoxib are both non-steroidal anti-inflammatory drugs, the two pharmacological effects are similar, through the inhibition of cyclo-oxygenase enzyme so that the body’s prostaglandins to reduce, so as to play an anti-inflammatory, analgesic effect. The difference is that celecoxib is a selective cyclooxygenase 2 inhibitor, which is less damaging to the gastrointestinal tract. Adverse effects of diclofenac sodium include gastric discomfort, burning sensation, and acid reflux; it is contraindicated in those who are allergic to the drug, and those who have a history of active bleeding or gastrointestinal perforation. Adverse reactions to celecoxib include dyspepsia, diarrhea, abdominal pain, and rash; it is contraindicated in patients who are allergic to the drug, allergic to sulfonamide, and have active peptic ulcers/bleeding. The use of diclofenac sodium enteric-coated tablets should be noted with caution in patients with hepatic or renal impairment or a history of ulcers; should be used with caution in patients with restricted sodium intake; avoid combining the drug with other non-steroidal anti-inflammatory drugs, including selective cox-2 inhibitors. The use of celecoxib is cautioned against a possible increase in serious cardiovascular thrombotic events; avoid the concomitant use of multiple nonsteroidal anti-inflammatory drugs. It is recommended that patients use medications under the supervision of a physician, and consult a physician for specific advice on the choice of diclofenac sodium enteric-coated tablets and celecoxib.