A red patch on the scalp of a patient with SLE may be associated with SLE disease activity. Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that occurs in young women, mostly in their 20s and 40s, and involves multiple organs. There are many specific manifestations, such as butterfly-shaped erythema, discoid erythema, etc. An erythema on the scalp may be an inflammatory skin manifestation of SLE, which may be related to SLE disease activity. The treatment of SLE includes psychological and spiritual support as well as medication, which is mainly based on non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, anti-malarials, glucocorticosteroids such as prednisone and immunosuppressants such as merti-macrolide. If there is a red spot on the scalp, it is recommended to go to the rheumatology and immunology department of the regular hospital, dermatology and other related departments, and follow the doctor’s instructions.