1. Chronic phase (CP), which can last 1 to 3 years. The white blood cell count is significantly higher, with a significant increase in neutrophils and a predominance of intermediate, late and rod-shaped granulocytes, and ≤10% primitive cells. More than 95% of CML cells have Ph chromosomes with t(9;22)(q34;q11 bands, forming a BCR-ABL fusion gene encoding protein P210. 2. Accelerated phase (AP), often with fever, weakness, progressive weight loss, gradual bleeding and anemia. The previously effective drugs become ineffective. There are very obvious laboratory test features. ① blood or bone marrow primitive cells ≥ 10%; ② peripheral blood basophils > 20%, neutrophils significantly increased, with neutrophils in the middle, late and rod-shaped nuclei granulocytes; ③ unexplained progressive reduction or increase of platelets; ④ in addition to Ph chromosomes and other chromosomal abnormalities such as +8, double Ph chromosomes, i17q, etc.; ⑤ bone marrow biopsy suggests significant proliferation of collagen fibers. 3.Acute transformation stage (BP), the end stage of slow-granulocytic leukemia, the clinical manifestations are similar to acute leukemia, and the prognosis of acute transformation is extremely poor. The clinical manifestations are similar to those of acute leukemia, and the prognosis of acute transformation is extremely poor.