初诊的慢性粒细胞白血病治疗策略调整―第二代络氨酸激酶抑制剂在慢粒一线治疗中的作用 Evolving treatment strategies for patients newly diagnosed with chronic myeloid leukemia: the role of second-generation BCRCABL inhibitors as first-line therapyP J Shami and M Deininger河南省肿瘤医院血液科刘新建AbstractIn patients with chronic myeloid leukemia (CML), disease in the initial chronic phase (CP) and subsequent progression are driven by the oncogenic activity of the BCRCABL fusion kinase. Imatinib, a tyrosine kinase inhibitor of BCRCABL, has been the mainstay of first-line therapy for CML for 10 years. Although patients with CMLCCP respond well to imatinib, those who have delayed reductions in leukemic burden during imatinib therapy, such as not achieving a complete cytogenetic response (CCyR) by 12 months, have an increased risk of disease progression. It has been recognized, with 8 years of observation, that patients who achieve an early major molecular response ( For more information, please contact me. Thank you! Henan Provincial Institute of Hematology Liu Xinjian Gleevec aid for patients with chronic granulocytic leukemia in Henan Province New Agricultural Cooperative Process 1. Bring the report card of bone marrow cell morphology, chromosome, fusion gene, etc., medical record and diagnosis certificate for diagnosis of chronic granulocytic leukemia to the local Agricultural Cooperative Office to get the application form (i.e. Annex I after the document, if the local Agricultural Cooperative does not have it, you can directly copy Annex I). Make three copies, affix photos and seal. At the same time, apply for outpatient electronic referral to Henan Cancer Hospital. (Note: If the patient is being hospitalized, he/she needs to go through the discharge procedure before he/she can go through the outpatient referral procedure.) 2. Bring three copies of application form, outpatient electronic referral form, ID card, agricultural cooperation book, household register, medical records and all information to the provincial tumor hospital (intersection of Dongming Road and Weiwu Road). 3. The registered doctor registers the patient’s medical records and prescribes three copies (one copy to be kept in the hospital, one copy to be sent to the Charity Federation and one copy for reimbursement by the Civil Affairs Bureau for low income households). The maximum number of boxes of medicine to be taken at a time (to avoid side effects or changes in the condition can not continue to take the medicine can not be returned, and unnecessary financial losses). 4, to the second floor of the outpatient clinic to review the documents, for registration. 5, payment (monthly costs of about 24,000 yuan, only pay 20%, that is, 4,800 yuan. The remaining 80% will be advanced by the hospital and later settled by the hospital and the local agricultural cooperative). 6. Make 4 copies of the invoice and take it back to the doctor for stamping (one copy to be sent to the General Charity Federation, one copy to be used for reimbursement by the Civil Affairs Bureau for low-income households, one copy to be kept at the doctor’s office, and one copy to be retained by the patient). 7. The registered doctor fills out an application form for charitable assistance and applies for free medication for the 4th to 12th month. The application form should be stamped by the local township or township government. 8. In the second and third months, you do not need to apply to the local agricultural cooperative, but take the original application form and come directly to buy the prescription. If you are hospitalized, you still need to apply again at the Agricultural Cooperative after the discharge procedure.9. After 2 months of medication, review the bone marrow cell morphology, chromosomes, fusion genes, etc., and register with a doctor to fill out a medical evaluation letter.10. Send the 3-month prescriptions, copies of invoices, charity aid application forms, medical evaluation letters, copies of ID cards, copies of family register, and copies of the Agricultural Cooperative book or card to the China Charity Federation in Beijing. Wait for the notification from the Charity Federation. After the fourth month of notification, the patient must go to the registered doctor’s office to get a free prescription and collect the medicine from the provincial charity federation once a month.12. Repeat the above procedures for the second year and apply again, but do not need to go to the township government for stamping. For further information, please contact: Liu Xinjian, Chief Physician, Department of Hematology, Henan Cancer Hospital 0371-65587310