Breast cancer with axillary lymphatic metastasis in locally advanced stage can be treated, and it is necessary to choose surgical treatment, chemotherapy, radiotherapy, endocrine therapy, targeted therapy, immunotherapy, etc. according to the condition. Breast cancer is one of the most common malignant tumors in women. If axillary lymph node metastasis occurs in patients with breast cancer, if the body can tolerate it, it is feasible to perform modified radical mastectomy for breast cancer, and at the same time, axillary lymph nodes can be cleared at the same time. After surgery, follow-up treatment will be considered according to the size of the lesion and the number of lymph node metastases, pathologic type and other factors. Patients with lymphatic metastasis usually also need chemotherapy. Some patients with positive immunohistochemical indexes also need to undergo appropriate endocrine and targeted therapy. For PD-L1-positive breast cancer patients, combined immunotherapy can also be used to further improve the therapeutic effect. After standardized treatment, most of the patients with locally advanced breast cancer can have a better prognosis. It is recommended that patients go to regular hospitals in time for consultation and standardized treatment under the guidance of professional doctors.