Hypointense images in the liver can be seen in these conditions: first, hemangioma of the liver, which can be found as a hypointense lesion with smooth margins on CT examination. Secondly, metastatic tumors in the liver, which should be multiple lesions, and can be found as edematous bands around the tumor, more obvious on enhanced CT, showing the bull’s-eye sign, and multiple lesions in the liver, combined with abnormal liver function and significant increase in bilirubin and transaminases. The third type, primary hepatocellular carcinoma, is an isolated lesion, which can also show a special image of fast-in and fast-out after enhancing contrast. For primary hepatocellular carcinoma, early stage patients can choose surgery; while for lesions like hemangioma, regular follow-up observation is possible.