Growing pimples that are hard and painful on the face may be polymerized acne or acne co-infection, which requires timely adjustment of lifestyle habits, topical and/or oral medication, and phototherapy to alleviate the symptoms. 1. Adjust lifestyle habits: Do not use cosmetics for the time being, avoid irritating cleaning products, avoid exposure to the sun, and minimize external stimuli to the skin. At the same time, adjust the routine, try to go to bed early and get up early. Do not use your hands to squeeze acne, so as not to aggravate the condition. 2. Topical drugs: such as adapalene gel, benzoyl peroxide gel, erythromycin ointment, fusidic acid cream, azelaic acid cream. 3. Oral medications: such as isotretinoin, spironolactone tablets, minocycline, doxycycline, etc. 4. Physical therapy: If the lesions are mild to moderate, red and blue light irradiation can be used. If scarring has occurred, fractional laser can be used. It is recommended that patients consult a doctor in a timely manner, the above treatments should be used under the guidance of a doctor to exclude relevant contraindications, to avoid self-induced haphazard treatment.