The treatment of hypertrophic obstructive cardiomyopathy mainly includes drug treatment, surgical treatment, and other treatments. 1.Drug therapy. The preferred drugs are β-blockers such as bisoprolol, which can reduce left ventricular outflow tract obstruction, and non-dihydropyridine calcium channel blockers such as diltiazem extended-release, which can also reduce left ventricular outflow tract obstruction. In the presence of heart failure, angiotensin-converting enzyme inhibitors such as captopril and spironolactone can be used for treatment, with caution with digoxin. Amiodarone can be used to reduce episodes of paroxysmal atrial fibrillation. 2. Surgery. For the ineffective drug treatment, heart failure is more serious, or there is severe outflow tract obstruction, surgical treatment can be adopted, commonly used surgical methods include septal septectomy. 3. Other treatments. Alcohol septal ablation can also improve the symptoms of heart failure. Dual-chamber pacing can be used if medication is not effective and surgery or ablation is not indicated. If you are diagnosed with hypertrophic obstructive cardiomyopathy, you should follow your doctor’s instructions for specific treatments and medications.