Big toenail pain in the flesh may be related to inguinitis, heredity, gray nails and other reasons, need to be on the cause of drug treatment, surgical treatment, physical therapy to solve. 1. For those caused by onychomycosis, the use of povidone-iodine solution can reduce the redness, swelling and pain to avoid infection; those who have pus can take ceftriaxone and other antibiotics orally; according to the specific circumstances, we can choose the whole nail or part of the nail plate extraction and other surgical procedures; for the early stage of the patient, the carbon dioxide laser and other physical methods can destroy the nail root of the nail matrix, so that this part of the growth of the new nail plate. 2. For nail deformities caused by heredity, nail extraction or nail correction surgery can be chosen under the advice of doctors. 3. For nail deformation caused by gray nail, you can follow the doctor’s advice to use drugs such as amorphophallus hydrochloride, oral itraconazole capsules and other drugs for treatment; depending on the specific circumstances, you can choose nail extraction. It is recommended that people with painful big toe nails go to the hospital in time for standardized treatment under the guidance of a doctor.