Psoriasis patients with infectious diseases such as tuberculosis, hepatitis B, the presence of malignant tumors, and recent vaccinations are not recommended to undergo treatment with biological agents. 1. Infectious diseases: biologics are not recommended for psoriasis patients with active tuberculosis, hepatitis B virus infection and abnormal liver function, which may lead to further progression or deterioration of the disease. 2. Malignant tumors: Psoriasis people who are diagnosed with or have suffered from malignant tumors, such as lymphatic system, are not recommended to be treated with biological inhibitors, which may potentially lead to tumor progression. 3. Recent vaccination: the application of biological agents may affect the effect of vaccination, so the application of biological agents is not recommended for recent inactivated or recombinant vaccination. 4. Others: The application of biologics for treatment is also not recommended for people such as women who are planning to become pregnant, or those with mild psoriasis. When the diagnosis of psoriasis requires biological treatment, it should be applied under the guidance of a doctor.