Gastric sinus mucosal bulge usually cannot be self-healed and requires treatment. Gastric sinus mucosal bulge may be benign lesions, such as smooth muscle tumor, mesenchymal tumors, if the bulge is less than 0.5cm, can be temporarily observed; if greater than 0.5cm, need to endoscopic submucosal stripping treatment; may also suggest inflammatory hyperplasia, can be given to the acid suppression drugs such as omeprazole, magnesium alumina carbonate and other gastric mucosal protective agents, generally a better prognosis. Gastric sinus mucosal bulge may also be malignant lesion, histopathological biopsy should be taken under gastroscope, and those who are diagnosed as gastric cancer should be actively treated with surgery, including open surgery and endoscopic surgery, and can also be combined with chemotherapy, radiotherapy, etc. to prolong the survival period. Gastric sinus mucosal bulge should go to the hospital in time and be treated under doctor’s guidance to avoid delaying the condition.