HP is Helicobacter pylori, HP retest is still positive, need to assess the impact of HP on the body, can be treated by medication and other related measures. HP positive treatment can not be converted to negative, need to carry out the first H. pylori treatment program evaluation, or H. pylori culture + drug sensitivity, the choice of sensitive antibiotics + high-quality proton pump inhibitors, can be added with probiotics to improve the antimicrobial effect. If there are resistance factors to H. pylori eradication (greater than 70 years of age, hepatic and renal dysfunction, etc.), regular follow-up gastroscopy is required to understand the effect of HP on the stomach. In addition, if the patient has symptoms of gastrointestinal bleeding can be treated surgically, and common surgical methods include endoscopic treatment and surgery. Patients need to go to the hospital, follow the doctor’s instructions for treatment, and the application of drugs need to strictly follow the doctor’s instructions.