“The antihypertensive drug with the smallest side effects is Irbesartan” is not a good idea, whether the side effects of antihypertensive drugs and their severity vary from person to person, there is no absolute minimum. Irbesartan belongs to the angiotensin II receptor blocking drugs, is currently one of the first-line anti-hypertensive drugs, suitable for the treatment of primary hypertension, combined with hypertension type 2 diabetic nephropathy. However, there is no authoritative study on the comparison of the side effects of various antihypertensive drugs, and the occurrence of side effects and their severity can be individualized depending on the individual’s physical condition, other therapeutic measures and other factors. Therefore, it can not be concluded that Irbesartan is the antihypertensive drug with the least side effects. It should also be noted that Irbesartan is contraindicated in people who are allergic to it, women in the 4th to 9th month of pregnancy and breastfeeding, and there may be adverse reactions such as dizziness, nausea, vomiting, fatigue, upright hypotension and skeletal muscle pain during the course of the medication. It should be noted that this product should not be used in combination with angiotensin-converting enzyme inhibitors (ACEIs) in patients with diabetic nephropathy. Therefore, patients with diagnosed hypertension should choose the medication under the guidance of a doctor in combination with the actual situation of the individual, and pay attention to observe the efficacy of the medication and the reaction, and consult a doctor in a timely manner if any discomfort occurs. Do not blindly use drugs or increase or decrease the dosage of drugs by yourself to avoid adverse consequences.