The symptoms of uremia in children are the same as those of uremia in adults. The main manifestations are loss of appetite, nausea, vomiting, anemia, significantly elevated blood pressure, edema, and in some cases, severe chest tightness, breath-holding, and telangiectatic breathing. Once various kidney diseases progress to the uremic stage, the kidneys basically lose the ability to detoxify and drain as well as promote hematopoiesis. Toxins are represented by myohepatitis and urea, and when toxins cannot be excreted, they will accumulate in the body, damaging not only various organs but also affecting the digestive tract. Patients may suffer from loss of appetite, nausea and vomiting. The retention of water in the body will manifest itself as edema and elevated blood pressure in mild cases, and will cause symptoms of heart failure in severe cases. The symptoms of heart failure are mainly chest tightness, breath-holding, and telangiectatic breathing. Another function of the kidneys is to produce erythropoietin, which promotes hematopoiesis. When kidney disease progresses to the uremic stage, the production of erythropoietin decreases, the regulation of hematopoiesis decreases, and patients will become anemic, manifesting as pale face or nails, general weakness, and shortness of breath after a little activity, etc.