Liver depression and spleen deficiency is a very common clinical evidence in TCM. When encountering liver depression and spleen deficiency, literally liver depression is liver qi stagnation, so we have to de-stagnate the liver and relieve depression. Spleen deficiency is spleen qi deficiency, liver qi stagnation, spleen qi deficiency. The liver qi stagnation should be de-stagnant, spleen qi deficiency to strengthen the spleen and benefit the qi, by strengthening the spleen and benefit the qi, de-stagnate the liver to treat the disease. The representative formula is Free and Easy San. The first three flavors of the medicine Chai Hu, Radix Angelicae Sinensis and Bai Shao are good for relieving liver stagnation, while the last two or three flavors of fried Atractylodes Macrocephala and Poria are good for strengthening the spleen. The patient’s basic formula is prolotherapy, which detoxifies the liver and strengthens the spleen, but each patient’s focus is not exactly the same, some of them are mainly suffering from liver stagnation and qi stagnation, for example, the detoxification of the liver and qi is not strong enough, then add the medicine to detoxify the liver and qi, yujin and preciosa to detoxify the liver and qi. Some patients even have pains in the ribs, so they add jinlingzi san, than yuan hu and neem. If the spleen deficiency is heavier, to spleen deficiency is the main, in addition to Atractylodes and Poria, you can add Radix Codonopsis or Mu Xiang, Sharen, Yam, Lentil, to strengthen the effect of strengthening the spleen, in the clinic to be based on the specific circumstances of the patient, liver depression and spleen deficiency which is more or less important, specific application of treatment is better.