Clindamycin Metronidazole Applicator works to kill Propionibacterium acnes and reduce the production of fatty acids in the epidermis, and the side effects are mainly dry skin, local irritation and rash. Clindamycin Metronidazole Applicator is a compound preparation, the components include clindamycin hydrochloride and metronidazole, the former is an antibiotic, through the inhibition of bacterial protein synthesis and thus play an antibacterial role. The former is an antibiotic, which exerts antibacterial effect by inhibiting the protein synthesis of bacteria, and the latter mainly acts as an anaerobic antimicrobial agent. The two drugs together can exert the above effects, and are mainly used in the treatment of acne vulgaris, seborrheic dermatitis, folliculitis, and rosacea. Some patients may experience local irritation (such as burning sensation, redness, swelling, tingling, etc.), allergic reactions (such as rashes, etc.), skin dryness and other adverse reactions during the use of the drug, in which case the drug should be washed off immediately, and if it is not relieved, prompt medical attention should be sought. It should be noted that the use of clindamycin metronidazole application is prohibited for those who are allergic to any components of the drug, pregnant women, nursing mothers, the drug can not be used for a long time on a large area, and avoid contact with the eyes and other mucous membrane parts when using. Patients should follow the doctor’s instructions to use clindamycin metronidazole applicator, avoid blindly using the drug on their own, so as not to induce side effects.