Pain and pressure in the submandibular gland is one of the symptoms of submandibular adenitis. Retrograde inflammation of the submandibular gland due to obstruction and narrowing of the duct is called submandibular adenitis and is often complicated with salivary stones. The main clinical manifestations are enlargement of the submandibular gland, pain, and purulent discharge from the duct opening. It is most common in young adults, more males than females, with a short history of a few days and a long history of several years or more. So, what is the differential diagnosis of submandibular gland pain and pressure pain? Here is a brief introduction. 1, chronic submandibular adenitis manifested as a mass in the submandibular area, with a history of repeated enlargement, the mass is generally not more than 2cm in diameter, the submandibular gland duct opening is normal without post-feeding enlargement and salivary colic symptoms, X-ray contrast radiography for normal submandibular gland images. 2, submandibular gland tumors often show persistent enlargement, generally no inflammatory manifestations, anti-inflammatory treatment is ineffective, malignant tumors often involve the lingual nerve sublingual nerve facial nerve mandibular margin branch, causing the corresponding dysfunction submandibular gland imaging can be seen as an occupying lesion. 3, acute odontogenic submandibular cellulitis is the same as acute submandibular adenitis, manifested as acute inflammation, but without the history and clinical manifestations of chronic submandibular adenitis, the oral cavity has obvious odontogenic lesions. Patients are advised to quit smoking and alcohol, prevent cold and flu, and avoid spicy foods . Active anti-inflammatory treatment. Enhance oral hygiene, drink more acidic beverages, and make incision and drainage if there is abscess limitation.