Wrist pain on exertion or rotation can be relieved with general treatment, medication, physical therapy, and surgery depending on the cause, which may be due to myofasciitis, trauma, arthritis, and other causes. 1. Myofasciitis: wrist pain when exerting or rotating may be caused by myofasciitis, oral non-steroidal anti-inflammatory drugs to treat, such as ibuprofen or naproxen, etc., but also for hot compresses, grilled electricity and other physical therapy, severe cases can be injected drugs for local closed treatment, such as betamethasone, lidocaine and other drugs. 2. Trauma: after a fall, the wrist hits the ground, which may lead to joint damage in the wrist area, causing pain when the wrist is exerted or rotated, cold compresses can be applied to the affected area in the acute stage, and hot compresses can be applied after the acute stage, supplemented by massages to promote blood circulation, and safflower oil can also be applied locally to alleviate the pain. If there is a fracture, you can consider the fracture incision and internal fixation surgery for treatment. 3. Arthritis: Arthritis may be caused when the wrist joint or its surrounding tissues are affected by inflammation or infection. Oral non-steroidal anti-inflammatory drugs, such as ibuprofen, indomethacin, etc., can be taken, and in severe cases, surgery, such as joint cleaning, is needed. Wrist pain may be caused by other reasons when you exert yourself or rotate your wrist. If the pain persists, it is recommended that you go to a regular hospital in time for a medical examination to determine the cause of the pain, and then follow the doctor’s instructions to carry out targeted treatment. Do not blindly use drugs to avoid adverse consequences.