After taking omeprazole black stool, to first clarify the cause of black stool is food or drug factors, or upper gastrointestinal bleeding, and then according to the cause of the targeted treatment, such as stop taking the food or drugs that cause black stool, gastroscopy and other examinations, the use of inhibition of gastric acid secretion and hemostasis of the drug, surgical treatment and so on. Omeprazole is a proton pump inhibitor, which can reduce the secretion of gastric acid, thus reducing the stimulating effect of gastric acid on gastric mucosa. Normally, taking omeprazole does not cause black stools. When black stools occur after taking this drug, on the one hand, we should exclude dietary and medication factors causing black stools, such as consuming too much spinach, animal blood products, etc., or taking medications containing iron-based agents, such as ferrous succinate and ferrous sulfate, etc., which may also result in black stools. The symptoms of black stool can be relieved after stopping the consumption of the above foods and taking the above medicines. If the black stool is caused by non-food factors, it is necessary to rule out the existence of upper gastrointestinal bleeding, such as gastritis, gastric ulcer, drug stimulation, etc. leading to gastric and duodenal bleeding. In this case, we should consult a doctor in time, carry out gastroscopy and other examinations to clarify the cause, and take the inhibition of gastric acid secretion drug omeprazole, lansoprazole, etc. under the guidance of the doctor, to inhibit the secretion of gastric acid, and to reduce the stimulation of the gastric mucosa. The use of posterior pituitary hormone, growth inhibitors to stop bleeding and other treatments, the symptoms of severe cases may require surgical treatment. After taking omeprazole and passing black stools, and after excluding dietary and medication factors, you must consult a doctor in time to avoid delaying your condition.