Edema of the limbs may be related to physiological factors or pathological factors such as heart failure, acute glomerulonephritis, nephrotic syndrome and so on. 1. Physiological factors: poor daily habits, such as sedentary, squatting, standing, etc., will lead to poor blood circulation, which may lead to the emergence of edema of the extremities. 2.Pathologic factors: (1) Heart failure: mainly due to myocarditis, myocardial infarction, etc., resulting in ventricular diastolic function and heart pumping ability is impaired caused. It often shows shortness of breath, fatigue, edema, etc., which may lead to the appearance of limb edema. (2) Acute glomerulonephritis: It is mainly caused by bacterial, viral and parasitic infections, and can also be induced by alcoholism and drugs. It often shows hematuria, decreased urine output, hypertension, edema and so on, which may lead to edema of limbs. (3) Nephrotic syndrome: mainly caused by genetics, infection, immunity, drugs, environmental factors, etc., often showing a large amount of proteinuria, edema, hyperlipidemia, etc., which may lead to the emergence of edema in the limbs. Therefore, if the situation of edema in the limbs does not improve, it is recommended to consult a doctor as soon as possible to find out the cause.