Hepatic ultrasound coarse echogenicity, which generally refers to coarse echogenicity of liver parenchyma, is an ultrasound manifestation of diffuse liver lesions. The main causes are hepatitis B, hepatitis A, hepatitis C, jaundiced hepatitis, fatty liver, and alcoholic liver. These liver diseases cause the liver stellate cells to generate a large amount of collagen deposited between liver cells, causing different degrees of liver damage. Long-term liver damage is caused by viruses or chemical drugs, and if left untreated, liver tissue will undergo fibroplasia as well as nodular regeneration of hepatocytes leading to cirrhosis. In the ultrasound performance is the liver parenchymal echogenicity rough, uneven, liver envelope is not smooth, liver volume will become smaller, so regular ultrasound examination of the liver and liver function test is very necessary.