Radiofrequency ablation for liver cancer is a kind of minimally invasive treatment. Post-operative pain is usually related to adverse reaction after radiofrequency ablation, inflammation and infection as well as cancerous pain, which needs to be treated with general treatment, medication or surgery according to the cause of disease. 1. Adverse reaction after radiofrequency ablation: radiofrequency ablation is to carry out treatment by passing electric current through the tumor, which may cause pain during the operation. Oral painkillers, such as aspirin, ibuprofen, etc., should be taken as prescribed by doctor in time. 2. Inflammation and infection: If the postoperative care is not proper, wound infection and inflammation will cause pain. At present, we need to pay attention to local hygiene, prevent secondary infection, and if the pain is serious, we can take aspirin for pain relief as prescribed by the doctor, and take cephalosporin (e.g., cefoperazone, etc.), penicillin (e.g., amoxicillin, etc.) and other anti-inflammatory medicines orally. 3. Cancer pain: the pain caused by cancer itself can be alleviated by oral medication, such as aspirin, ibuprofen, etc. If the cancer spreads to other surrounding tissues, radiotherapy or chemotherapy should be taken as soon as possible to inhibit the cancer cells. In case the tumor has not spread, if it meets the indication of surgery, the tumor should be removed in time. If the pain is serious after radiofrequency ablation surgery for liver cancer, it is necessary to consult a doctor in time and take pain-relieving or other treatments under the guidance of a professional doctor to avoid unauthorized use of drugs.