Drinking cola on the first day does not usually affect blood glucose measurement on the next day in normal people; drinking cola on the first day in diabetic patients may affect blood glucose measurement on the next day. The main ingredients of cola include water, carbon dioxide, sugar, etc. The large amount of sugar in cola will raise blood sugar. In normal people, drinking cola on the first day may lead to a slight increase in blood glucose on the next day, but generally the blood glucose result will still be within the normal range; diabetic patients cannot metabolize sugar well due to insufficient insulin secretion or impaired utilization, so drinking cola on the first day may affect the next day’s blood glucose measurement. It is recommended to ensure adequate sleep, emotional stability, avoid strenuous exercise, and refrain from drinking food and beverages after 10:00 p.m. on the day before the blood glucose measurement, otherwise it may affect the results of the next day’s blood glucose measurement, especially fasting blood glucose. Drinking a large amount of cola the day before the blood glucose test is not recommended, but if necessary, inform your doctor.