Hand, foot and mouth disease vaccine is necessary. Hand, foot and mouth disease is a relatively common viral infectious diseases in children, due to the lack of effective antiviral drug treatment, the infection is mainly symptomatic treatment, effective preventive measures is to vaccinate against hand, foot and mouth disease, through the vaccine can be effective in preventing severe hand, foot and mouth disease caused by enterovirus 71 infections, so there is a need to be vaccinated against hand, foot and mouth disease vaccine. Hand, foot and mouth disease is caused by enterovirus infection, of which enterovirus 71 infection caused by severe hand, foot and mouth disease is the most harmful, easy to lead to neurogenic pulmonary edema and other serious complications and endangered the child’s life, and hand, foot and mouth disease vaccine is mainly used for the prevention of enterovirus 71 infection, which can reduce the incidence of severe hand, foot and mouth disease. Vaccination should be carried out at a regular vaccination institution, consult the physician at the vaccination site before vaccination to rule out contraindications, and observe the vaccination site for half an hour after vaccination before leaving.