Long-term proteinuria and eye edema, common causes include nephrotic syndrome, chronic nephritis, lupus nephritis and so on, need to take medication according to the cause of the disease, commonly used drugs include diuretics, hormones and immunosuppressant and so on. 1. Nephrotic syndrome: large amount of proteinuria, eyelid edema and other symptoms may occur. Furosemide, torasemide and other drugs can be taken to diuretic swelling, can also take glucocorticoid drug therapy to play an anti-inflammatory role, such as prednisone and so on. 2. Chronic nephritis: patients can appear proteinuria, edema and other symptoms, mostly manifested as face, hands, abdominal edema. Furosemide and other diuretic drugs can be used to eliminate edema, or angiotensin-converting enzyme inhibitors such as Benadryl, etc., which can relieve proteinuria and delay the deterioration of renal function. 3. Lupus nephritis: mainly manifested as proteinuria and hematuria, which may be accompanied by edema symptoms, but most of them are mainly depressed edema of calves, and a few of them may have puffy eyes. It can be treated with oral or intravenous cyclophosphamide, or with drugs such as tacrolimus. Prolonged urinary protein, eye edema causes more, it is recommended to timely consultation, identify the cause of the disease to take symptomatic treatment in accordance with the doctor’s instructions, do not self-medication, in order to avoid delaying the condition.