Gastric sinus pox-like erosion usually can not be self-healing, and need to be treated. Gastric sinus pox-like erosion is due to irregular diet, Helicobacter pylori infection and drug damage and other factors lead to erosion of the mucosa of the gastric sinus, is a manifestation of gastric inflammation, can appear epigastric pain, abdominal distension of the symptoms, and in severe cases, can be gastrointestinal bleeding. Gastric sinus pox-like erosion is the result of multiple causes of pathology, the need for medication and other standardized treatment such as omeprazole, thioglycollate, etc., to control inflammation, reduce the symptoms, if not intervene not only can not be self-healing but also lead to further progression of the disease. If the patient has gastric sinus pox-like erosion, it is recommended to go to the hospital in time, as soon as possible for treatment, so as to avoid adverse consequences.