Toothache may be caused by dental disease, periodontal disease or cardiovascular disease, and there are different treatments for different causes, such as root canal treatment and removal of irritating factors. 1. Dental disease. A toothache may be caused by pulpitis or periapical inflammation of the tooth. The easiest way to relieve the pain is to perform root canal treatment to remove the infected pulp. 2. Periodontal disease. Toothache may also be caused by food impaction gingival papillitis, this time with dental floss to remove the impaction after the pain can be significantly relieved, if the tartar caused by periodontal inflammation pain, need to be cleaned to remove the tartar, after periodontal treatment, the pain will also be significantly relieved. 3. Cardiovascular disease. Cardiovascular diseases such as heart attack can also lead to odontogenic pain, this time you need to take nitroglycerin under the tongue, and then immediately go to the hospital for examination and treatment, to prevent the impact on health. Toothache want to ease the pain, it is recommended to the hospital first clear cause after targeted treatment, the medication should follow the doctor’s instructions, not to self-medication.