Nattokinase should be taken at a normal maintenance dose of no less than 2,000 FU per day, depending on the individual. There is no “best way” to take Nattokinase, and it is recommended that it be taken under a doctor’s supervision. Nattokinase is a serine protease enzyme produced by Bacillus subtilis during the fermentation of natto, which has the effect of lowering blood viscosity, improving blood circulation, softening and increasing the elasticity of blood vessels. Nattokinase is contraindicated in people with severe diarrhea, vomiting, dyspepsia, patients who need to be treated with procoagulant medications, bleeding and oozing of blood from the skin and internal organs. Nattokinase has a half-life of 8 hours and is able to act in the body for 8 to 12 hours. The specific dosage depends on the individual’s specific situation, for normal or sub-healthy people used for the prevention of cardiovascular and cerebrovascular disease is recommended daily dosage of 2000FU, cardiovascular disease patients are recommended daily intake of 2000 to 5000FU, cardiovascular and cerebrovascular disease of patients with severe disease daily recommended intake of 5000 to 7000FU. People who need to take nattokinase are recommended to use it under the supervision of a doctor.