Ventricular premature beats of outflow tract origin are usually seen in patients without organic heart disease, and they are usually recurrent or persistent, with a high number of premature beats, sometimes accompanied by associated premature beats or short bursts of ventricular tachycardia. In recent years, radiofrequency catheter ablation has achieved good efficacy in the treatment of premature ventricular beats in the outflow tract and has become a safe and effective method for the treatment of these diseases. In our hospital, 125 cases of premature ventricular beats in the outflow tract were treated with radiofrequency ablation between June 2004 and May 2011 with good results. The average age of this group was 45.2±11.9 years, the average duration of disease was 5.0±5.1 years, and the longest duration was 32 years. The average number of 24-hour ventricular premature beats was 16888±7486, the least number of premature beats was 4800, and the most number of premature beats was 42000. Frequent premature ventricular beats may affect hemodynamics, reducing coronary blood flow by 20%, cerebral blood flow by 12%-25%, and renal blood flow by 8%-10%, and may induce angina pectoris or cardiac insufficiency, or even tachycardic cardiomyopathy. Most patients have obvious symptoms, which seriously affect the quality of life, and even affect the function of the heart, causing symptoms such as exertional shortness of breath and dizziness. Radiofrequency ablation for ventricular outflow tract ventricular premature has its clinical therapeutic value and social benefits. In this group of cases, the patients’ palpitation symptoms disappeared after RFCA. 11 of them combined with organic heart disease, which obviously affected the patients’ cardiac function due to the high number of premature beats, and their symptoms improved significantly after RFCA was performed. The procedure of radiofrequency ablation for premature ventricular ejection tract is relatively simple and can be successfully performed by using conventional intracardiac electrophysiological examination and radiofrequency ablation. The success rate of RFCA for premature exiting ventricle is high. The success rate of RFCA in this group of cases was 97.22%. The data of RFCA treatment in this group showed that RFCA treatment of premature ventricular outflow tract has high success rate, high safety, few surgical complications, and good long-term follow-up, which is one of the preferred methods of radical treatment, and may be more meaningful for patients with combined organic heart disease.