Conservative treatment of appendicitis will not lead to early menstruation in most cases, because menstruation is mainly affected by the ovaries’ cyclic secretion of estrogen and progesterone, which is related to the uterus itself, and appendicitis is a localized inflammatory reaction of the appendix, which can be controlled by anti-inflammatory treatment. If appendicitis requires surgical treatment, it may cause early menstruation because the cleaning of the abdominal cavity during appendicitis surgery may stimulate the ovaries, leading to temporary endocrine changes and early menstruation. It is recommended to strengthen the care during menstruation and change sanitary napkins regularly. In addition, the vast majority of menstruation will return to normal the next time.