Chest tightness with pressure sensation in the chest may be related to cardiogenic diseases, digestive system diseases, respiratory diseases and so on. 1. Cardiogenic diseases: such as coronary heart disease can be manifested in chest tightness, a sense of pressure, the need for electrocardiography, coronary angiography and other tests to clarify. 2. Digestive system diseases: chest pressure chest tightness if it is after meals, need to consider bile reflux gastritis, duodenal ulcer, etc., gastric acid secretion abnormalities may cause chest tightness. 3. Respiratory diseases: such as pleurisy or even lung tumors, in addition to the symptoms of chest tightness with pressure, there may also be chest pain, cough and other symptoms. Chest pressure, chest tightness has a variety of possible causes, it is recommended to go to the hospital in a timely manner to improve the relevant examination, identify the causes of treatment under the guidance of the doctor.