In patients with failing systemic conditions, if coughing and coughing up sputum are labored and accompanied by impaired consciousness, routine aspiration is required and the airway should be kept open. When a patient develops a cough with respiratory distress, immediate aspiration is required. For patients who are very sick, sputum sounds can be heard at the patient’s bedside in both lungs, and in patients on ventilators, when the airway line pressure rises significantly and there is a continuous high pressure alarm, and the patient monitor indicates a sudden drop in oxygen saturation, when this occurs, sputum aspiration is needed in a timely manner. The frequency of aspiration in patients is mainly determined by their conditions, with some patients requiring aspiration once every hour or even at shorter intervals, and some patients requiring aspiration at four-hour intervals. Before and after aspiration, it is necessary to use high concentration oxygen for two minutes each, which can effectively prevent asphyxia.