The incubation period of 3~5 days, with low fever, general discomfort, abdominal pain and other antecedents. 1~2 days in the oral cavity, pharynx, soft palate, buccal mucosa, tongue, gingiva appeared painful corn grain to mung bean size blisters, surrounded by a red halo, broken into small ulcers, due to the pain, salivation and refusal to eat. At the same time the hands and feet also appear rash, in the hands and feet of the dorsal surface and fingers (toes) dorsal edge, around the nail, palm and plantar part, the appearance of a variable number of blisters, in addition to the hands, feet and mouth, can also be seen on the buttocks and near the anus, and occasionally in the trunk and limbs, a few days after the drying up, subside, the rash is not itchy, no pain. Individual children may have generalized papules and blisters, accompanied by aseptic meningitis, encephalitis and myocarditis. Generally well-passed, the full course of the disease is about 5 to 10 days, most of which can be self-cured and have a good prognosis. When hand, foot and mouth disease occurs, the sick child often start with fever, its fever varies, there are also those who do not have fever, but with low fever mostly about half of the points. And often accompanied by salivation, runny nose, sore mouth, sore throat and anorexia and other symptoms. Clinical herpes of the oral cavity, hands and feet as the main features. Oral herpes is seen on the tongue, buccal mucosa, hard palate, lips, pharynx and tonsils, about 3mm in size, and quickly breaks down to form ulcers. Rash is mostly seen in the distal part of the hands and feet, fingers between the fingers, the edge of the heel and peri-nail, palms and metatarsals are also common, the lower limbs and buttocks can be densely distributed pimple-like rash, initially maculopapular, and then transformed into a herpes, round or oval, about 3~7mm such as the size of a grain of rice, smaller than the chickenpox rash, the texture of the hard, surrounded by a reddish halo. The number of herpes is less than a few and more than dozens. The general course of the disease is relatively light and short, more than 1 week or so healed, the rash subsides without scarring or pigmentation, such as secondary infections often make the skin damage aggravated. Hand, foot and mouth disease can be seen all year round, with more in summer and fall. The onset of the disease is characterized by fever, cough, runny nose and drooling like an upper respiratory tract infection, and some children may have nausea and vomiting. Later, oval or pike-shaped blisters appear on the backs of fingers and toes of hands and feet, with a red halo around the blisters, the liquid of the blisters is clear, and the long axis of the blisters is consistent with the skin pattern. Then the centers of the blisters are sunken, yellow, dry, and peel off (desquamation). There are also scattered, firmer, light red papules or herpes on the ends of the fingers and toes. Also, there are scattered blisters in the mouth, such as on the lips, tongue, oral mucosa, and gums, but the blisters in the mouth quickly break and form grayish-white dots or a grayish-white layer of membrane, which is surrounded by a reddish halo, and punctate or lamellar vesicles can be seen under the grayish-white membrane. Hand, foot and mouth disease is caused by viral infection, the source of infection is herpes fluid, throat secretions, fecal contamination of hands, toys, eating utensils, etc.. Its incubation period is 3-8 days. According to the epidemiological characteristics, the diagnosis is confirmed by the presence of herpes in the oral cavity, hands and feet, and the isolation and culture of the COX A19 virus in throat swabs, blood and blister fluid. Hand, foot and mouth disease should be differentiated from foot and mouth disease. First, the pathogen is different The pathogen of foot-and-mouth disease is foot-and-mouth disease virus, which is a zoonotic pathogen. Hand, foot and mouth disease is caused by several kinds of enterovirus infection. Second, the source of infection is different foot-and-mouth disease virus only causes even-toed hoofed (two and a half hooves) animals cattle, sheep, pigs, deer, camels, etc. foot-and-mouth disease, foot-and-mouth disease has become the source of infection. It is only when a veterinary disease appears first that a person can be made ill. Hand, foot and mouth disease is the source of infection of patients and intestinal virus-carrying people, belonging to human disease. Third, the transmission pathway is different foot-and-mouth disease is through contact with the sick animal oral cavity, hoof crown of the ulcerated spots, through the skin and mucous membrane infections; occasionally also consumed by the virus infected and not heated (pasteurization) of the milk infection. Therefore, human foot-and-mouth disease is extremely sporadic. HFMD is contracted orally through contact with the patient, through contamination of daily necessities, eating utensils, toys, and can also be transmitted through the respiratory tract. Therefore, different scale epidemics can occur. Fourth, the incidence of different groups of people suffering from foot-and-mouth disease is determined by contact with sick animals, the age of the incidence of a wide range of people, but due to the susceptibility is very low, the chance of disease is very small. Children and the elderly once the disease symptoms are more serious. Hand, foot and mouth disease is mainly young children infectious diseases, children under 3 years of age accounted for the vast majority of unclear, rarely more than 5 years of age or older. 1983 tianjin epidemic hand, foot and mouth disease, the incidence rate of children under 3 years of age is 32.85 ‰, 3 ~ 6 years of age is 14.23 ‰, 7 ~ 14 years of age is 1.27 ‰, 15 years of age or older 0.05 ‰. Often in the nursery institutions appear epidemic. Fifth, the symptoms of different pieces of foot-and-mouth disease, hand-foot-and-mouth disease, although the site of the disease in the oral cavity, between the fingers, toes have similarities, but the symptoms and signs are different. Foot-and-mouth disease is mainly manifested as systemic symptoms of poisoning and local herpes damage two major features. Fever, headache, general malaise, 1~2 days after the oral mucosa, tongue, fingers, toes blisters, and then 1~2 days blisters burst, the formation of rotten spots, secondary infection into pustules, and then scab, fall off, generally do not leave a scar. Duration of the disease 1 ~ ` 2 weeks, most of the prognosis is good, serious cases can be complicated by myocarditis. Most cases of HFMD do not have fever or low fever, but have symptoms of respiratory tract infection. First in the oral mucous wax appear herpes, distribution and buccal mucosa, gums, tongue edge, and break into ulcers. Immediately in the fingers, feet, buttocks, knees appear papules, the next day only a small number of papules form herpes, such as mung beans, red small beans large, single sex does not fuse, containing clear liquid, the end does not break, 3 ~ 5 days self-absorption contraction. Systemic symptoms are light, the disease duration of about a week, the prognosis is good. Sixth, the diagnosis is based on different foot-and-mouth disease need to first have local livestock foot-and-mouth disease occurs or epidemic, and have the opportunity to contact with diseased animals, or drinking diseased animals contaminated and unheated milk and other infections relationship. Incubation period of 2 ~ 18 a friend 3 ~ 8 days common; the onset of systemic toxic symptoms and local herpes, ulcer damage two characteristics. It needs to be differentiated from herpes pharyngitis and herpes simplex. In terms of prevention, attention should be paid to the epidemic in the summer, as little as possible to take children to public places, weekday education of children to develop good hygiene habits, to do before meals, after washing hands; toys, tableware to be regularly disinfected. Early detection, early treatment, early isolation. If the disease is prevalent in a nursery or kindergarten, the first thing to do is to isolate the affected children from healthy children and disinfect the toys with disinfectant. You can put honeysuckle, Herba Euphorbiae, raw Job’s tears, big green leaves (i.e., the leaves of Panax quinquefolium), and licorice into water, boil it, and then pour it out 20 minutes later and drink it as a tea. Three to five days can be, but weak, easy to diarrhea children do not drink. For children with herpes in the mouth, ulcers, and smelly breath, in addition to the above formula, you can also use lampblossom, patchouli, gypsum, fengfeng, and tamarind leaves in decoction, which can clear heart fire. For children with loss of appetite can also add malt to the Lampsia formula to open the stomach. If the child has herpes on the hands and feet, then external cleansing can be used, using wild chrysanthemum, comfrey, groundnut, bitter ginseng, etc. Boil and soak the hands and feet when it cools to a moderate temperature, in order to play a role in clearing the heat, resolving dampness and cooling the blood.