Sulphonylureas are insulinotropic agents, including sulfonylureas and glinides. Adverse effects of sulfonylureas include hypoglycemia, gastrointestinal discomfort, etc. Adverse effects of glinides include damage to liver and kidney function and low potassium. 1. Sulfonylureas: When patients use sulfonylureas in larger dosages, such as glimepiride, glipizide, etc., it will lead to a significant decrease in blood sugar in the body, which is easy to induce hypoglycemia, and the patient suffers from a variety of symptoms such as fatigue, coma, etc. The drug may also cause abdominal pain, gastrointestinal discomfort, and other adverse effects. The drug may also cause abdominal pain, bloating and other gastrointestinal symptoms. 2. Glargine-type drugs: Glargine-type drugs, such as Repaglinide and Naglinide, are mainly metabolized in the liver and kidneys, etc., and when taken in large quantities for a long period of time, it is easy to cause damage to the cells in the above mentioned areas, which may easily affect the functions of the liver and kidneys. The drug may also cause low blood potassium, lead to abnormal blood calcium, affect bone metabolism and other adverse reactions. Patients are advised to use insulinotropic secretagogues under the guidance of professional physicians to prevent obvious harm to the body.