Unexplained ankle pain may be caused by gouty arthritis, ankle arthritis, lumbar disc herniation and so on. 1. Gouty arthritis: a common manifestation of gout patients, mostly seen in the ankle, the first metatarsophalangeal joints and other places. It is often caused by the intake of high-purine food, drinking a lot of alcohol, resulting in local pain, redness and swelling and other symptoms. You can take colchicine tablets and loxoprofen sodium tablets for analgesic and anti-inflammatory treatment as prescribed by the doctor. In daily life, you need to pay attention to local warmth, avoid intake of high purine food, do not drink a lot of alcohol. 2. Ankle arthritis: Ankle arthritis caused by chronic injury and degenerative lesions of the ankle joint, patients will experience pain and restricted movement. In the acute stage, you can take non-steroidal anti-inflammatory drugs under the guidance of the doctor for treatment, such as Nimesulide dispersible tablets. Cold compresses can also be applied to relieve the inflammatory manifestations of the disease. Patients with severe symptoms can be treated with sodium hyaluronate injections into the ankle joint under the guidance of a doctor. 3. Lumbar intervertebral disc herniation: Herniated intervertebral disc compresses the surrounding nerve roots, causing numbness, pain and other abnormal symptoms in the innervated area, such as ankle pain, numbness in the lower limbs and so on. It is necessary to avoid prolonged sitting and standing in daily life. For serious cases, medication can be prescribed, such as tizanidine hydrochloride tablets and celecoxib capsules. If conservative treatment is ineffective, surgical treatment is needed. Unexplained ankle pain can also be caused by other reasons such as varicose veins and arterial embolism, etc. It is recommended to consult a doctor as soon as possible to determine the cause of the problem before treatment.