Patient: January 14, 2009, the onset of the disease is mainly swollen and painful joints, morning swelling, cough, not known before the onset of the body butterfly erythema, and then automatically disappeared, the complement 0.19, then hospitalized for half a month, the complement back to 0.41, after discharge from the hospital treatment oral prednisone 10, the end of March check the complement back to 0.61, now oral prednisone two, but often have a headache dizziness, weakness phenomenon. After being discharged from the hospital, I took 10 capsules of prednisone orally, and at the end of March, I was checked to see if I had 0.61. I am now taking two capsules of prednisone orally, but I often have headaches, dizziness, and weakness, and I often have mouth ulcers and irregular bowel movements. Can there be a better treatment method? Cai Xiaoyan, Director of the Department of Rheumatology and Immunology, Guangzhou First People’s Hospital: SLE is a chronic autoimmune disease that can affect any tissues and organs of the body, not only the skin and joints, but also the kidneys, blood system, brain, heart and lungs, etc. Therefore, it should be treated systematically for a long time and should not be treated anxiously. Generally speaking, SLE cannot be treated by hormone therapy alone. It needs to be strengthened by choosing appropriate immunosuppressive agents according to the activity of the disease and the degree of organ damage, such as: methotrexate, cyclophosphamide, azathioprine, mycophenolate, leflunomide, cyclosporine, etc. The application of immunosuppressants has the following effects: on the one hand, it can reduce the amount of hormones, and another more important aspect is to effectively control the disease, prevent relapse and stop the occurrence of organ damage. For some patients with severe disease, some biological agents can also be applied for targeted therapy at present to remove the over-activated immune cells that produce autoantibodies. There is no curative surgery for SLE. However, despite the fact that there is no cure, the treatment of SLE is much more advanced than it was a decade or two ago. Patients with SLE have longer survival periods and a significantly better quality of life, and many can work and live normally and even become pregnant and have children after systematic treatment.