There is no single best treatment for granulomatous mastitis. The treatment needs to take into account the patient’s specific condition to receive medication, surgery and other treatments to improve the symptoms. 1. Drugs: The onset of granulomatous mastitis is often associated with infection by pathogenic microorganisms such as bacteria, and antibiotics such as levofloxacin can be used as prescribed by the doctor to control the local inflammatory reaction. 2. Surgery: In patients with granulomatous mastitis, a localized abscess forms in the breast. Surgery may be needed to drain the pus. If the patient is not cured for a long time, or if the patient fails to recover after several incisions and drains, the patient can be treated with unilateral total excision of the mammary gland, preservation of the skin and nipple, and implantation of a prosthesis. In addition, surgical treatment is also needed when the lesion is limited. There may be other clinical treatments for granulomatous mastitis. It is recommended to visit the breast surgery department of the hospital as soon as possible and cooperate with the doctor for treatment.