The causes of high C-reactive protein fever in children are mainly due to the following two types of conditions. The first is caused by bacterial infection, because after suffering from bacterial infection, it will lead to an increase in the level of white blood cells in the body, as well as an increase in the blood C-reactive protein value, which can be treated promptly with antibiotics, such as the application of cephalosporin and erythromycin, etc. Second, due to immune system diseases, if suffering from rheumatic fever or Kawasaki disease, especially after suffering from Kawasaki disease, there will be high fever persistently, often more than five days, and C-reactive protein is very high, for Kawasaki disease, to promptly carry out gammaglobulin anti-allergy treatment.