Hypertension is the most common chronic disease and the most important risk factor for cardiovascular disease. Major complications such as stroke, myocardial infarction, heart failure and chronic kidney disease can occur if blood pressure is poorly controlled over time. Therefore, lowering the blood pressure level of patients can significantly reduce stroke and cardiac events and significantly improve the quality of life of patients. Nowadays, hypertension treatment is generally achieved by taking antihypertensive drugs, but in clinical practice, we find that many patients with hypertension lack scientific knowledge of medication, although they use a lot of antihypertensive drugs, but the effect of antihypertensive is still not ideal, and there are many side effects, and even the phenomenon of blood pressure “rebound” and life-threatening. So how should patients take antihypertensive drugs in the process of lowering blood pressure? The following will give you to take antihypertensive drugs need to pay attention to the place. The common antihypertensive drugs used in the treatment of hypertension (1) beta-blockers: such as metoprolol, atenolol, bisoprolol, carveolol, labetalol, etc. (2) Calcium channel antagonists: such as nifedipine, verapamil and diltiazem. (3) Diuretics: such as thiazides, tabular diuretics and potassium-protective diuretics, etc. (4) Angiotensin inhibitors: such as captopril, enalapril, benazepril, and cilazepril. (5) Angiotensin II receptor blockers: such as coxsartan, etc. Precautions for taking antihypertensive drugs Start with small doses You should not rush or lower blood pressure quickly during taking antihypertensive drugs, but follow the basic principle of gradual progress to avoid adverse reactions caused by insufficient perfusion of major organs. The use of antihypertensive drugs for the treatment of hypertension should generally start with a small dose, so that not only the possible efficacy can be obtained but also the adverse effects can be minimized. If the blood pressure does not reach the control target, then increase the dose of the corresponding antihypertensive drugs according to the dosing situation to obtain the best efficacy. “Fight the long war” When patients have secondary hypertension, paroxysmal hypertension, or mild hypertension, once they have obvious indications for medication they usually need to receive lifelong treatment with long-term antihypertensive drugs. The practice of intermittent medication, where the blood pressure drops and the patient stops taking antihypertensive medication, should be avoided. This is because intermittent medication can easily cause blood pressure to rebound, and in the process of rebounding, the target organs can unknowingly suffer more damage. Preventing blood pressure fluctuations Usually the best choice of antihypertensive drugs for patients with non-spoon type hypertension is the long-acting form, because the half-life of such drugs reaches 24 hours, which is conducive to a smooth lowering of blood pressure, avoiding sudden high and low blood pressure throughout the day, and only once a day, the patient is not easy to forget and avoid blood pressure fluctuations caused by missed doses of drugs. For patients with spoon type hypertension, it is best to choose to take short-acting doses of antihypertensive drugs before the peak of hypertension to ensure that the blood pressure is stable within the target range for 24 hours a day. Only by reducing fluctuations in blood pressure can target organ damage be effectively prevented. (Spoon type blood pressure: human normal blood pressure in 24 hours has a circadian rhythm of two peaks and one valley, generally speaking 7:00 a.m. to 11:00 a.m. and 3:00 p.m. to 7:00 p.m. blood pressure is at a higher level, while at night when sleeping, blood pressure drops 10-20%, called the night valley, the valley is generally at 0-3 hours. Non-spoon blood pressure, i.e., blood pressure drops by less than 10% at night compared to daytime). Reasonable scheduling of medication Making the blood pressure of hypertensive patients let control within a reasonable range and keep the blood pressure stable is the purpose of taking antihypertensive drugs. If the patient is prone to blood pressure fluctuations in the morning, it is best to take antihypertensive medication immediately after waking up, so as to effectively avoid the “morning danger moment”. If ambulatory blood pressure monitoring shows poor blood pressure control at night, medication should be taken before bedtime. Therefore, the timing of hypertension medication needs to be reasonably adjusted according to the fluctuation of blood pressure. The combination of two or more antihypertensive drugs can be used in order to increase the antihypertensive effect without increasing the adverse effects, and the combination of antihypertensive drugs is often required for grade 2 or higher hypertension to achieve the target blood pressure. Combination therapy can effectively interfere with multiple antihypertensive mechanisms, enhance the antihypertensive effect, prolong the duration of the antihypertensive effect, reduce or offset the adverse effects, and protect target organs. In the past decade, antihypertensive therapy has evolved from single-agent sequential regimens to combination regimens and has become the dominant clinical antihypertensive therapy. The above “tips” on antihypertensive drugs are not set in stone, there are more than 200 kinds of antihypertensive drugs in China, and patients with hypertension need to use the drugs under the guidance of a doctor to achieve the best results, do not choose and change drugs on their own by hearsay, Do not choose and change drugs on your own.