One-time radical treatment of perianal abscess refers to incision and drainage of the abscess, treatment of the internal opening, and hanging treatment to avoid the formation of anal fistula. Perianal abscess is a common suppurative infectious disease in the anal area, in the patient’s anus around the formation of a harder swelling, which is filled with purulent secretions and decayed tissue, the patient will have a more intense pain. If left untreated, an anal fistula may form, increasing the severity of the disease. Perianal abscesses can be treated with a one-time radical surgery, which requires local anesthesia before the procedure, and then requires thorough disinfection of the outside of the anus as well as the inside of the anal canal. An incision is made to locate the area with the most pus, and all the purulent secretions and decaying tissue inside are drained. Immediately following this, the area is treated by flushing with hydrogen peroxide, finding the internal opening, removing it, treating it, and draining it thoroughly by hanging a wire to leave the abscess completely open. The area is then flushed and a drain and vent tube are placed. At the end of the procedure, regular dressing changes are required while avoiding infection in the wound area by giving antibiotics ceftriaxone and ciprofloxacin as anti-infective treatment. Once suffering from perianal abscess, you need to consult the doctor in time, under the guidance of the doctor to carry out appropriate treatment, to avoid delaying the aggravation of the condition. The above drugs are used as prescribed by the doctor.